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Ann Oncol. 2011 Jun;22(6):1332-8. doi: 10.1093/annonc/mdq595. Epub 2010 Dec 3.

Carbohydrate intake, glycemic load, glycemic index, and risk of ovarian cancer.

Author information

1
Gynaecological Cancer Group, Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia. Christina.Nagle@qimr.edu.au

Abstract

BACKGROUND:

Our objective was to determine the relationship between dietary glycemic load (GL), glycemic index (GI), carbohydrate intake, and ovarian cancer risk in a population-based case-control study.

PATIENTS AND METHODS:

A self-administered questionnaire was used to collect data on demographic and lifestyle factors, and a food frequency questionnaire was used to collect dietary information from 1366 women with ovarian cancer and 1414 population controls.

RESULTS:

GL was positively associated with ovarian cancer. The adjusted odds ratio (OR) for the highest versus the lowest quartile of intake was 1.24 [95% confidence interval (CI) 1.00-1.55, P for trend = 0.03]. Fiber intake was inversely associated with risk. The OR comparing women in the highest fiber-intake group with those in the lowest was 0.78 (95% CI 0.62-0.98, P for trend = 0.11). We found no association between GI, carbohydrate intake, and ovarian cancer. In analyses stratified by body mass index, the risk estimates for GL, carbohydrate, and sugar were higher among overweight/obese women; however, the interaction term was only significant for sugar (P for interaction = 0.004).

CONCLUSIONS:

Our results suggest that diets with a high GL may increase the risk of ovarian cancer, particularly among overweight/obese women, and a high intake of fiber may provide modest protection.

PMID:
21131370
DOI:
10.1093/annonc/mdq595
[Indexed for MEDLINE]

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