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Curr Opin Immunol. 2011 Feb;23(1):46-56. doi: 10.1016/j.coi.2010.10.021. Epub 2010 Dec 3.

Tripartite-motif proteins and innate immune regulation.

Author information

1
Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.

Abstract

The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.

PMID:
21131187
DOI:
10.1016/j.coi.2010.10.021
[Indexed for MEDLINE]

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