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Fertil Steril. 2011 Apr;95(5):1813-5.e1. doi: 10.1016/j.fertnstert.2010.11.019. Epub 2010 Dec 3.

Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy loss.

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Department of Internal Medicine and Chest Diseases, Brest University Hospital, La Cavale Blanche Hospital, Brest, France.


Compared with 537 parous controls with no history of pregnancy loss, a lower thrombomodulin-related inhibition of the endogenous thrombin potential was measured in 264 cases with previous unexplained pregnancy loss, especially when losses occurred between 9 and 12 weeks of gestation. Adjusting age, protein S, factor VIII, factor V Leiden, and prothrombin G20210A did not change the results.

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