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Best Pract Res Clin Haematol. 2010 Dec;23(4):519-23. doi: 10.1016/j.beha.2010.09.011. Epub 2010 Nov 18.

Can every patient be mobilized?

Author information

1
Washington University School of Medicine, St Louis, Missouri 63110, United States. jdipers@dom.wustl.edu

Abstract

There are several ways to mobilize hematopoietic stem cells for autologous and allogeneic hematopoietic stem cell transplant by manipulating the bone marrow microenvironment. Granulocyte colony-stimulating factor (G-CSF) and chemotherapy have been commonly used to mobilize stem cells, but several new agents, such as the CXCR4 inhibitor plerixafor, inhibit stromal-stem cell interactions to improve stem cell yield. The minimum threshold for engraftment is 2 × 10⁶ CD34+ cells/kg, but it has been shown that higher CD34+ stem cell dose, such as 5 × 10⁶ CD34+ cells/kg, is associated with improved survival. Efforts to increase stem cell yield remain important to improve outcomes.

PMID:
21130416
DOI:
10.1016/j.beha.2010.09.011
[Indexed for MEDLINE]

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