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Best Pract Res Clin Haematol. 2010 Dec;23(4):463-8. doi: 10.1016/j.beha.2010.09.017. Epub 2010 Nov 1.

Epigenetics in AML.

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  • 1Weill Cornell Medical College, New York, NY 10065, United States. amm2014@med.cornell.edu

Abstract

Epigenetic regulation is known to affect gene expression, and recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. All leukemias display aberrant distribution of cytosine methylation, which is most notably distributed in specific and distinct signatures in acute myeloid leukemia (AML). These signatures reflect leukemic mechanisms and have clinical and prognostic significance. Compared with genetic lesions in AML, epigenetic lesions appear to be more frequent and recurrent.

PMID:
21130408
DOI:
10.1016/j.beha.2010.09.017
[PubMed - indexed for MEDLINE]
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