Format

Send to

Choose Destination
Trends Biotechnol. 2011 Mar;29(3):110-8. doi: 10.1016/j.tibtech.2010.10.006. Epub 2010 Dec 2.

Purpose-driven biomaterials research in liver-tissue engineering.

Author information

1
National University of Singapore, MD9 #03-03, 2 Medical Drive, Singapore.

Abstract

Bottom-up engineering of microscale tissue ("microtissue") constructs to recapitulate partially the complex structure-function relationships of liver parenchyma has been realized through the development of sophisticated biomaterial scaffolds, liver-cell sources, and in vitro culture techniques. With regard to in vivo applications, the long-lived stem/progenitor cell constructs can improve cell engraftment, whereas the short-lived, but highly functional hepatocyte constructs stimulate host liver regeneration. With regard to in vitro applications, microtissue constructs are being adapted or custom-engineered into cell-based assays for testing acute, chronic and idiosyncratic toxicities of drugs or pathogens. Systems-level methods and computational models that represent quantitative relationships between biomaterial scaffolds, cells and microtissue constructs will further enable their rational design for optimal integration into specific biomedical applications.

PMID:
21129798
DOI:
10.1016/j.tibtech.2010.10.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center