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J Pathol. 2011 Jan;223(2):230-40. doi: 10.1002/path.2788. Epub 2010 Oct 25.

Genetically informed lung cancer medicine.

Author information

1
Vanderbilt-Ingram Cancer Center, Department of Medicine/Division of Hematology-Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. william.pao@vanderbilt.edu

Abstract

Knowledge of tumour mutation status has become increasingly important for the prioritization of targeted therapies for cancer. We review here the major known 'driver' mutations with therapeutic relevance in non-small cell lung cancer. We also discuss a variety of methods now being employed in molecular diagnostic laboratories to detect genetic alterations in lung tumours. A genetically-informed approach to lung cancer medicine is rapidly becoming the standard of care worldwide and should lead to improved outcomes for patients.

PMID:
21125677
DOI:
10.1002/path.2788
[Indexed for MEDLINE]

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