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PLoS One. 2010 Nov 18;5(11):e14047. doi: 10.1371/journal.pone.0014047.

The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.

Author information

1
Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom.

Abstract

Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates, but the function of most of these receptors is still not understood. The orphan Adhesion-GPCR GPR126 has recently been shown to play an essential role in the myelination of peripheral nerves in zebrafish. In parallel, whole-genome association studies have implicated variation at the GPR126 locus as a determinant of body height in the human population. The physiological function of GPR126 in mammals is still unknown. We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development.

PMID:
21124978
PMCID:
PMC2987804
DOI:
10.1371/journal.pone.0014047
[Indexed for MEDLINE]
Free PMC Article

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