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PLoS One. 2010 Nov 23;5(11):e14094. doi: 10.1371/journal.pone.0014094.

JULIDE: a software tool for 3D reconstruction and statistical analysis of autoradiographic mouse brain sections.

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1
Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Abstract

In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. This software tool has been developed in the open-source ITK software framework and is freely available under a GPL license. The article presents the complete image processing chain from raw data acquisition to 3D statistical group analysis. Results of the group comparison in the context of a study on spatial learning are shown as an illustration of the data that can be obtained with this tool.

PMID:
21124830
PMCID:
PMC2991313
DOI:
10.1371/journal.pone.0014094
[Indexed for MEDLINE]
Free PMC Article
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