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Genes Dev. 2010 Dec 1;24(23):2583-6. doi: 10.1101/gad.2004510.

Herpes Simplex Virus is Akt-ing in translational control.

Author information

1
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA.

Abstract

All viruses depend on the cellular protein synthesis machinery for the production of viral proteins. Thus, viruses have evolved a variety of strategies to avoid innate host responses that inhibit protein synthesis. In this issue of Genes & Development, Chuluunbaatar and colleagues (pp. 2627-2639) demonstrate that Herpes Simplex Virus-1 counteracts this response through viral kinase Us3, which mimics cellular kinase Akt to phosphorylate and repress tuberous sclerosis complex 2 (TSC2), resulting in the activation of mammalian target of rapamycin complex 1 (mTORC1) and enhancement of mRNA translation.

PMID:
21123644
PMCID:
PMC2994031
DOI:
10.1101/gad.2004510
[Indexed for MEDLINE]
Free PMC Article

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