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Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a004143. doi: 10.1101/cshperspect.a004143.

Regulation by Ca2+-signaling pathways of adenylyl cyclases.

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1
Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, United Kingdom.

Abstract

Interplay between the signaling pathways of the intracellular second messengers, cAMP and Ca(2+), has vital consequences for numerous essential physiological processes. Although cAMP can impact on Ca(2+)-homeostasis at many levels, Ca(2+) either directly, or indirectly (via calmodulin [CaM], CaM-binding proteins, protein kinase C [PKC] or Gβγ subunits) may also regulate cAMP synthesis. Here, we have evaluated the evidence for regulation of adenylyl cyclases (ACs) by Ca(2+)-signaling pathways, with an emphasis on verification of this regulation in a physiological context. The effects of compartmentalization and protein signaling complexes on the regulation of AC activity by Ca(2+)-signaling pathways are also addressed. Major gaps are apparent in the interactions that have been assumed, revealing a need to comprehensively clarify the effects of Ca(2+) signaling on individual ACs, so that the important ramifications of this critical interplay between Ca(2+) and cAMP are fully appreciated.

PMID:
21123395
PMCID:
PMC3003456
DOI:
10.1101/cshperspect.a004143
[Indexed for MEDLINE]
Free PMC Article
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