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Cold Spring Harb Perspect Biol. 2011 Mar 1;3(3). pii: a003285. doi: 10.1101/cshperspect.a003285.

Leukocytes in mammary development and cancer.

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1
Department of Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 94143, USA.

Abstract

Leukocytes, of both the innate and adaptive lineages, are normal cellular components of all tissues. These important cells not only are critical for regulating normal tissue homeostasis, but also are significant paracrine regulators of all physiologic and pathologic tissue repair processes. This article summarizes recent insights regarding the trophic roles of leukocytes at each stage of mammary gland development and during cancer development, with a focus on Murids and humans.

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PMID:
21123394
PMCID:
PMC3039933
DOI:
10.1101/cshperspect.a003285
[Indexed for MEDLINE]
Free PMC Article
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