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Clin Neurophysiol. 2011 Jun;122(6):1179-82. doi: 10.1016/j.clinph.2010.10.042. Epub 2010 Nov 30.

Resting-state EEG in schizophrenia: auditory verbal hallucinations are related to shortening of specific microstates.

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1
University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland.

Abstract

OBJECTIVE:

Abnormal perceptions and cognitions in schizophrenia might be related to abnormal resting states of the brain. Previous research found that a specific class (class D) of sub-second electroencephalography (EEG) microstates was shortened in schizophrenia. This shortening correlated with positive symptoms. We questioned if this reflected positive psychotic traits or present psychopathology.

METHODS:

Resting-state EEGs of frequently hallucinating patients, indicating on- and offset of hallucinations by button press, were analyzed. Microstate class D duration was related to spontaneous within-subject fluctuations of auditory hallucinations.

RESULTS:

Microstate D was significantly shorter in periods with hallucinations.

CONCLUSIONS:

Microstates of class D resemble topographies associated with error monitoring. Its premature termination may facilitate the misattribution of self-generated inner speech to external sources during hallucinations.

SIGNIFICANCE:

These results suggest that microstate D represents a biological state marker for hallucinatory experiences.

PMID:
21123110
DOI:
10.1016/j.clinph.2010.10.042
[Indexed for MEDLINE]
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