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Bioorg Med Chem Lett. 2011 Jan 1;21(1):294-8. doi: 10.1016/j.bmcl.2010.11.016. Epub 2010 Nov 5.

Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata.

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  • 1BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Republic of Korea.

Abstract

The emergence of highly pathogenic influenza A virus strains, such as the new H1N1 swine influenza (novel influenza), represents a serious threat to global human health. During our course of an anti-influenza screening program on natural products, one new licochalcone G (1) and seven known (2-8) chalcones were isolated as active principles from the acetone extract of Glycyrrhiza inflata. Compounds 3 and 6 without prenyl group showed strong inhibitory effects on various neuraminidases from influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, the efficacy of oseltamivir with the presence of compound 3 (5 μM) was increased against H274Y neuraminidase. This evidence of synergistic effect makes this inhibitor to have a potential possibility for control of pandemic infection by oseltamivir-resistant influenza virus.

PMID:
21123068
DOI:
10.1016/j.bmcl.2010.11.016
[PubMed - indexed for MEDLINE]
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