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Neural Dev. 2010 Dec 1;5:32. doi: 10.1186/1749-8104-5-32.

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.

Author information

1
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. liz.hammock@vanderbilt.edu

Abstract

BACKGROUND:

In an effort to identify genes that specify the mammalian forebrain, we used a comparative approach to identify mouse homologs of transcription factors expressed in developing Caenorhabditis elegans GABAergic neurons. A cell-specific microarray profiling study revealed a set of transcription factors that are highly expressed in embryonic C. elegans GABAergic neurons.

RESULTS:

Bioinformatic analyses identified mouse protein homologs of these selected transcripts and their expression pattern was mapped in the mouse embryonic forebrain by in situ hybridization. A review of human homologs indicates several of these genes are potential candidates in neurodevelopmental disorders.

CONCLUSIONS:

Our comparative approach has revealed several novel candidates that may serve as future targets for studies of mammalian forebrain development.

PMID:
21122108
PMCID:
PMC3006369
DOI:
10.1186/1749-8104-5-32
[Indexed for MEDLINE]
Free PMC Article

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