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Mil Med. 2010 Nov;175(11):913-6.

The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients.

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1
Division of Pulmonary and Critical Care, Department of Internal Medicine, East Tennessee State University, Johnson City, TN 37614, USA.

Abstract

BACKGROUND:

Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance.

OBJECTIVE:

We studied the link between sleep apnea and microvascular diabetic complications in veterans with type 2 diabetes mellitus (DM-2).

DESIGN:

A retrospective electronic chart of all veterans referred for sleep studies over a 1-year period was reviewed. Ninety-eight patients with a glycosylated hemoglobin < 6.5% were included in the study. The degree of glycemia (HbA1c) and presence of macro- and microvascular complications were compared with OSAS variables.

METHOD:

Statistical analysis examined bivariate associations between OSAS variables and metabolic syndrome parameters.

RESULTS:

The apnea hypopnea index was significantly related to diabetic microvascular complications, particularly retinopathy. Oxygen desaturation was significantly and inversely related to microalbuminuria, microvascular complications, retinopathy, and HbA1c.

CONCLUSIONS:

Sleep apnea is associated with microvascular complications even in well-controlled DM-2 veterans.

CLINICAL IMPLICATIONS:

Screening for OSAS should be considered in patients with DM-2.

PMID:
21121505
[Indexed for MEDLINE]
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