Format

Send to

Choose Destination
Adv Drug Deliv Rev. 2011 May 30;63(6):441-55. doi: 10.1016/j.addr.2010.11.002. Epub 2010 Nov 29.

Formation, characterization, and fate of inhaled drug nanoparticles.

Author information

1
MAP Pharmaceuticals, Inc., Mountain View, CA 94043, USA.

Abstract

Nanoparticles bring many benefits to pulmonary drug delivery applications, especially for systemic delivery and drugs with poor solubility. They have recently been explored in pressurized metered dose inhaler, nebulizer, and dry powder inhaler applications, mostly in polymeric forms. This article presents a review of processes that have been used to generate pure (non polymeric) drug nanoparticles, methods for characterizing the particles/formulations, their in-vitro and in-vivo performances, and the fate of inhaled nanoparticles.

PMID:
21118707
DOI:
10.1016/j.addr.2010.11.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center