Abstract
We present literature review on the role of excessive sodium consumption with food in pathogenesis of salt sensitive arterial hypertension (AH) as well as scientific data allowing to consider sensitivity to salt as independent factor of development and unfavorable course of AH associated with insulin resistance, high activity of sympathetic nervous system, and risk of cardiovascular complications. We present data on differential antihypertensive activity of drugs used for therapy of AH depending on sensitivity of patients to salt.
MeSH terms
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Antihypertensive Agents / therapeutic use*
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Blood Pressure / drug effects
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Disease Progression
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Humans
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Hypertension / metabolism*
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Hypertension / physiopathology
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Hypertension / therapy*
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Insulin / blood
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Kidney / drug effects
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Kidney / metabolism*
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Kidney / physiopathology
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Risk Factors
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Sodium Chloride, Dietary* / adverse effects
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Sodium Chloride, Dietary* / metabolism
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Sympathetic Nervous System / drug effects
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Sympathetic Nervous System / metabolism*
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Sympathetic Nervous System / physiopathology
Substances
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Antihypertensive Agents
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Insulin
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Sodium Chloride, Dietary