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Biochem Soc Trans. 2010 Dec;38(6):1645-9. doi: 10.1042/BST0381645.

Adapt or die: how eukaryotic cells respond to prolonged activation of the spindle assembly checkpoint.

Author information

1
Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA.

Abstract

Many cancer-treating compounds used in chemotherapies, the so-called antimitotics, target the mitotic spindle. Spindle defects in turn trigger activation of the SAC (spindle assembly checkpoint), a surveillance mechanism that transiently arrests cells in mitosis to provide the time for error correction. When the SAC is satisfied, it is silenced. However, after a variable amount of time, cells escape from the mitotic arrest, even if the SAC is not satisfied, through a process called adaptation or mitotic slippage. Adaptation weakens the killing properties of antimitotics, ultimately giving rise to resistant cancer cells. We summarize here the mechanisms underlying this process and propose a strategy to identify the factors involved using budding yeast as a model system. Inhibition of factors involved in SAC adaptation could have important therapeutic applications by potentiating the ability of antimitotics to cause cell death.

PMID:
21118141
DOI:
10.1042/BST0381645
[Indexed for MEDLINE]

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