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Anticancer Res. 2010 Nov;30(11):4485-92.

Effect of {beta}4 integrin knockdown by RNA interference in anaplastic thyroid carcinoma.

Author information

1
Division of Endocrinology, Institute of Endocrinology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Abstract

BACKGROUND:

Integrin α6β4 is a known tumor antigen; however, its function in different subtypes of thyroid cancer is not known. This study reports that α6β4 expression is selectively up-regulated in anaplastic thyroid cancer (ATC) cells, the most malignant subtype of human thyroid cancer.

MATERIALS AND METHODS:

To assess the contribution of α6β4 in ATC progression, cell proliferation, motility and soft agar assay were performed in vitro and a xenograft tumor growth assay was performed in vivo.

RESULTS:

Knockdown of β4 integrin subunit expression by shRNA in ATC cells reduced the proliferation, migration, and anchorage-independent growth of ATC cells in vitro and xenograft tumor growth in vivo.

CONCLUSION:

These data suggest that integrin α6β4 contributes to the development of aggressive forms of thyroid cancer with poor prognostic potential, such as ATC, and thus may be a novel therapeutic target for the treatment for this subtype of thyroid cancer.

PMID:
21115897
[Indexed for MEDLINE]

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