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J Am Soc Nephrol. 2010 Dec;21(12):2036-9. doi: 10.1681/ASN.2010050506. Epub 2010 Nov 29.

The effect of fructose on renal biology and disease.

Author information

1
Division of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado 80045, USA. richard.johnson@ucdenver.edu

Abstract

Dietary fructose intake is increasing. It is increasing primarily from added sugars, including sucrose and high fructose corn syrup, and correlates epidemiologically with the rising prevalence of metabolic syndrome and hypertension worldwide. The administration of fructose to animals and humans increases BP and the development of metabolic syndrome. These changes occur independently of caloric intake because of the effect of fructose on ATP depletion and uric acid generation. Fructose ingestion may also be a risk factor for kidney disease that includes glomerular hypertension, renal inflammation, and tubulointerstitial injury in animals. We suggest excessive fructose intake should be considered an environmental toxin with major health implications.

PMID:
21115612
DOI:
10.1681/ASN.2010050506
[Indexed for MEDLINE]
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