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Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):9-16. doi: 10.1098/rstb.2010.0276.

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing.

Author information

1
University of California, San Francisco, CA 94158, USA. cynthia.kenyon@ucsf.edu

Abstract

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in species throughout the animal kingdom. This life-extension pathway, the first to be defined, was discovered through genetic studies in the small roundworm Caenorhabditis elegans. This discovery is described here.

PMID:
21115525
PMCID:
PMC3001308
DOI:
10.1098/rstb.2010.0276
[Indexed for MEDLINE]
Free PMC Article

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