Format

Send to

Choose Destination
Bioinformatics. 2011 Feb 1;27(3):295-302. doi: 10.1093/bioinformatics/btq653. Epub 2010 Nov 26.

HiTEC: accurate error correction in high-throughput sequencing data.

Author information

1
Department of Computer Science, University of Western Ontario, London, ON N6A 5B7, Canada. ilie@csd.uwo.ca

Abstract

MOTIVATION:

High-throughput sequencing technologies produce very large amounts of data and sequencing errors constitute one of the major problems in analyzing such data. Current algorithms for correcting these errors are not very accurate and do not automatically adapt to the given data.

RESULTS:

We present HiTEC, an algorithm that provides a highly accurate, robust and fully automated method to correct reads produced by high-throughput sequencing methods. Our approach provides significantly higher accuracy than previous methods. It is time and space efficient and works very well for all read lengths, genome sizes and coverage levels.

AVAILABILITY:

The source code of HiTEC is freely available at www.csd.uwo.ca/~ilie/HiTEC/.

PMID:
21115437
DOI:
10.1093/bioinformatics/btq653
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center