Highly effective generic adjuvant systems for orphan or poverty-related vaccines

Vaccine. 2011 Jan 29;29(5):873-7. doi: 10.1016/j.vaccine.2010.11.049. Epub 2010 Nov 27.

Abstract

Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Adjuvants, Immunologic / adverse effects
  • Aluminum Hydroxide / administration & dosage
  • Aluminum Hydroxide / adverse effects
  • Animals
  • Anthrax / prevention & control
  • Anthrax Vaccines / adverse effects
  • Anthrax Vaccines / immunology*
  • Antibodies, Bacterial / blood
  • Antibodies, Neutralizing / blood
  • Liposomes / administration & dosage*
  • Liposomes / adverse effects
  • Macaca mulatta
  • Primate Diseases / prevention & control
  • Survival Analysis

Substances

  • Adjuvants, Immunologic
  • Anthrax Vaccines
  • Antibodies, Bacterial
  • Antibodies, Neutralizing
  • Liposomes
  • Aluminum Hydroxide