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J Sex Med. 2011 Feb;8(2):475-8. doi: 10.1111/j.1743-6109.2010.02130.x. Epub 2010 Nov 29.

Karyotyping, is it worthwhile in transsexualism?

Author information

1
Department of Endocrinology-Andrology, Center for Sexology and Genderproblems, Ghent University Hospital, Ghent, Belgium.

Abstract

INTRODUCTION:

Karyotyping is often performed in transsexual individuals.

AIM:

Quantification and characterization of karyotype findings and abnormalities in transsexual persons.

MAIN OUTCOME MEASURES:

Karyotypes were listed both in male-to-female and in female-to-male transsexual persons.

METHODS:

The data were collected through a retrospective study.

RESULTS:

Karyotypes of 368 transsexual individuals (251 male-to-female, 117 female-to-male) are described. Normal findings were found in 97.55%. Prevalence of abnormal karyotypes was 3.19% among male-to-female, and 0.85% among female-to-male transsexuals. Nine karyotypes showed variations; Klinefelter syndrome was confirmed in three persons, whereas others displayed autosomal aberrations.

CONCLUSION:

Karyotyping is only of very limited information in the transsexual population.

[Indexed for MEDLINE]

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