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Ann N Y Acad Sci. 2011 Jan;1217:77-82. doi: 10.1111/j.1749-6632.2010.05823.x. Epub 2010 Nov 29.

Why do T cells express the vitamin D receptor?

Author information

1
Department of Veterinary and Biomedical Sciences, The Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, Pennsylvania, USA. mxc69@psu.edu

Abstract

Vitamin D is an important regulator of immune function. T cells express the vitamin D receptor (VDR) and have been shown to be direct and indirect vitamin D targets. Why should T cells be responsive to vitamin D? The data suggest that expression of the VDR is required for the development of two cell types, NKT cells and CD8αα T cells, which inhibit autoimmunity. In addition, effector T cell cytokine production is regulated by vitamin D. Available evidence suggests that NKT and CD8αα T cells express the VDR as part of the selection process to protect against the generation of autoimmunity, particularly in the gut.

PMID:
21114675
PMCID:
PMC3129658
DOI:
10.1111/j.1749-6632.2010.05823.x
[Indexed for MEDLINE]
Free PMC Article
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