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Am J Reprod Immunol. 2011 Mar;65(3):279-83. doi: 10.1111/j.1600-0897.2010.00934.x. Epub 2010 Nov 28.

The role of the foreskin in male circumcision: an evidence-based review.

Author information

1
Northwestern University, Feinberg School of Medicine, 303 E Superior Street, Chicago, IL 60611, USA. m-dinh@northwestern.edu

Abstract

HIV sexual transmission via the male genital tract remains poorly defined. Male circumcision was shown to reduce female-to-male transmission in Africa, providing a clue that the foreskin plays a role in the route of transmission. Scientific data in four categories relating to how the foreskin might affect HIV transmission is summarized: (i) surface area, (ii) microbiologic environment, (iii) HIV-1-susceptible cells, and (iv) tissue structure. The relative contribution of each of these areas is yet unknown, and further studies will be crucial in understanding how male circumcision affects HIV transmission in men.

PMID:
21114567
PMCID:
PMC3091617
DOI:
10.1111/j.1600-0897.2010.00934.x
[Indexed for MEDLINE]
Free PMC Article

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