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Scand Cardiovasc J. 2011 Feb;45(1):21-6. doi: 10.3109/14017431.2010.536989. Epub 2010 Nov 30.

Troponin I and Creatine Kinase MB do not provide comparable information after PCI.

Author information

1
Department of Cardiology, University Hospital MAS, Malmoe, Sweden. CG@Gustavsson.se

Abstract

OBJECTIVES:

To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers.

DESIGN:

cTnI and CK-MB after PCI were stratified as multiples of the 99(th) percent upper reference limit (99%URL) and compared to each other in 489 patients. Post-PCI levels > three times 99%URL were classified as procedure-related infarctions. Results. After PCI, CK-MB was > 3x 99%URL in 58/486 patients (12%) and cTnI > 3x 99%URL in 292/487 patients (60%). cTnI was > 10x 99%URL in all cases with infarction according to CK-MB but CK-MB was often normal despite elevated cTnI. There was an only minimal overlap between two infarction populations, those with cTnI in the range from 1x to 10x 99%URL and those with CK-MB 1x to 10x 99%URL.

CONCLUSIONS:

With the present quantification scales, infarction rate after PCI is > five-fold higher with cTnI than with CK-MB.

PMID:
21114454
DOI:
10.3109/14017431.2010.536989
[Indexed for MEDLINE]
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