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Biomarkers. 2011 Feb;16(1):83-8. doi: 10.3109/1354750X.2010.533285. Epub 2010 Nov 29.

Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.

Abstract

BACKGROUND:

Predictive disease risk biomarkers that can be linked to exposure have proved difficult to identify in case-control studies.

METHODS:

Parallel statistical analysis of the correlation between (1)H NMR profiles from plasma samples collected before disease onset (EPIC cohort), versus exposure to dietary compounds, and follow-up disease endpoints (colon and breast cancer) was performed.

RESULTS:

Metabonomic signatures associated with colon cancer and dietary fiber intake (a protective factor according to epidemiological studies) were identified.

CONCLUSION:

This implementation of the novel "meet-in-the-middle" analytical strategy indicates how case-control studies nested in prospectively collected cohorts may reveal intermediate biomarkers linking exposure and disease.

PMID:
21114379
DOI:
10.3109/1354750X.2010.533285
[Indexed for MEDLINE]

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