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Clin Liver Dis. 2011 Feb;15(1):165-82. doi: 10.1016/j.cld.2010.09.001.

Dermatologic disorders and the liver.

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Long Island Jewish Medical Center at Albert Einstein College of Medicine, North Shore-Long Island Jewish Health system, 270-05 76th Avenue, New Hyde Park, NY 11040, USA.


Chronic liver disease is associated with several cutaneous manifestations. Although many of these changes are nonspecific, some are associated with distinct liver diseases and correlate with the severity of hepatic pathology. Often the first clue to a liver disease is manifested through skin. Although cirrhosis is associated with spider nevi and palmar erythema, disorders can result in noncirrhotic cutaneous manifestations. It is important for physicians to be familiar with the spectrum of these manifestations, to recognize, help detect, and treat the underlying hepatic disease. This article reviews the medical literature and discusses the spectrum of dermatologic manifestations of liver disorders and their pathogenesis, significance, and treatment.

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