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Neurobiol Dis. 2011 Mar;41(3):624-9. doi: 10.1016/j.nbd.2010.11.011. Epub 2010 Nov 24.

Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome.

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1
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA.

Abstract

Pregabalin, a Ca(2+) channel α(2)δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke. Pregabalin administration (5-10mg/kg, i.p.) 30-90 min after transient middle cerebral artery occlusion/reperfusion reduced infarct volume, neuronal death in the ischemic penumbra and neurological deficits at 24h post-stroke. Pregabalin significantly decreased the amount of Ca(2+)/calpain-mediated α-spectrin proteolysis in the cerebral cortex measured at 6h post-stroke. Together with the extensive clinical experience with pregabalin for other neurological indications, our findings suggest the potential for a therapeutic benefit of pregabalin in stroke patients.

PMID:
21111818
PMCID:
PMC3031782
DOI:
10.1016/j.nbd.2010.11.011
[Indexed for MEDLINE]
Free PMC Article
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