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Cell. 2010 Nov 24;143(5):682-5. doi: 10.1016/j.cell.2010.11.012.

Ubiquitin: same molecule, different degradation pathways.

Author information

1
Institute of Translational Medicine, University of Liverpool, UK. clague@liv.ac.uk

Abstract

Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrate toward a particular route of degradation likely include ubiquitin chain length and linkage type, which may favor interaction with particular receptors or confer differential susceptibility to deubiquitinase activities associated with each pathway.

PMID:
21111229
DOI:
10.1016/j.cell.2010.11.012
[Indexed for MEDLINE]
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