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Cell. 2010 Nov 24;143(5):667-8. doi: 10.1016/j.cell.2010.11.009.

SIRT3 in calorie restriction: can you hear me now?

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1
The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, 02114, USA.

Abstract

Caloric restriction decreases oxidative damage and extends life span in many organisms. Someya et al. (2010) show that the sirtuin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promoting the mitochondrial antioxidant system through the regulation of isocitrate dehydrogenase 2 (Idh2).

PMID:
21111225
DOI:
10.1016/j.cell.2010.11.009
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