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Cell Metab. 2010 Dec 1;12(6):555-6. doi: 10.1016/j.cmet.2010.11.016.

Lipotoxicity and the development of heart failure: moving from mouse to man.

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1
Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA. wstanley@medicine.umaryland.edu

Abstract

Intracardiac lipid accumulation can cause heart failure. A study in Journal of Clinical Investigation (Son et al., 2010) found that cardiac-specific PPARγ overexpression caused heart failure with intracardiac triglyceride accumulation. Overexpressing PPARγ on a PPARα-/- background improved cardiac function, suggesting that specific lipid metabolites and lipid packaging determine cardiac lipotoxicity.

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