Send to

Choose Destination
Neurosurgery. 2010 Dec;67(6):1515-22. doi: 10.1227/NEU.0b013e3181fa239e.

The Louisiana State University experience in the management of single small cerebellar metastasis.

Author information

Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103-33932



Cerebellar metastasis is often believed to be a more immediately life-threatening complication than brain metastasis in other locations. It is considered a negative prognostic factor in patients with systemic cancers. Despite its clinical importance and technological advances, the survival outcomes of patients with single small cerebellar metastases are rarely studied.


To retrospectively evaluate our experience in the management of patients with single small cerebellar metastasis and compare the treatment modalities.


A total of 35 patients with single small cerebellar metastasis were included in this retrospective analysis. Of the 35 patients, 24 had surgery followed by whole-brain radiation therapy and 11 had Gamma Knife radiosurgery alone.


The median survival for the whole cohort was 5.6 months after the intervention. No significant differences were noted in median survival between the surgery plus whole-brain radiation therapy and the Gamma Knife radiosurgery alone groups (6.3 months: 95% confidence interval [CI], 4.0-8.6; vs 5.0 months: 95% CI, 1.9-8.1; P=.9). There was no difference in the median time to local progression, distance progression, and overall progression between the 2 groups. Patients with hydrocephalus had a significantly lower survival rate (median, 3.3 months; 95% CI, 0.0-6.6) compared with those without hydrocephalus (median, 6.9 months; 95% CI, 4.4-9.8; P=.02). In the Cox regression model, the significant predictor of survival was hydrocephalus (P=.01; hazard ratio, 3.5; 95% CI, 1.3-9.1) after propensity score adjustment.


Treatment with Gamma Knife radiosurgery alone and surgery plus whole-brain radiation therapy were both efficacious in patients with single small cerebellar metastasis. Overall survival was nearly identical in both treatment groups.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center