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Fertil Steril. 2011 Mar 1;95(3):922-7. doi: 10.1016/j.fertnstert.2010.11.005. Epub 2010 Nov 24.

Latent celiac disease in reproductive performance of women.

Author information

1
Department of Obstetrics and Gynecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India. ashkumar@eth.net

Abstract

OBJECTIVE:

To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance.

DESIGN:

Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery.

SETTING:

Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi.

PATIENT(S):

Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases).

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy.

RESULT(S):

The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects.

CONCLUSION(S):

Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.

[Indexed for MEDLINE]
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