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J Am Chem Soc. 2010 Dec 22;132(50):17655-7. doi: 10.1021/ja106291e. Epub 2010 Nov 24.

Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures.

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1
Department of Biological Chemistry, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109-2216, United States.

Abstract

Alzheimer's disease (AD) is characterized by the self-assembly of amyloid beta (Aβ) peptides. Recent models implicate some of the earliest Aβ oligomers, such as trimers and tetramers, in disease. However, the roles of these structures remain uncertain, in part, because selective probes of their formation are not available. Toward that goal, we generated bivalent versions of the known Aβ ligand, the pentapeptide KLVFF. We found that compounds containing sufficiently long linkers (∼19 to 24 Å) recognized primarily Aβ trimers and tetramers, with little binding to either monomer or higher order structures. These compounds might be useful probes for early Aβ oligomers.

PMID:
21105683
PMCID:
PMC3005376
DOI:
10.1021/ja106291e
[Indexed for MEDLINE]
Free PMC Article
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