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World J Gastroenterol. 2010 Nov 28;16(44):5629-34.

Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines.

Author information

  • 1Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Tonghe Road 1838, Guangzhou 510515, Guangdong Province, China. baiyang1030@hotmail.com.

Abstract

AIM:

To evaluate the anti-Helicobacter pylori (H. pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.

METHODS:

A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H. pylori Sydney strain 1 was performed with broth dilution method. Anti-H. pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).

RESULTS:

The water extract from Rhizoma Coptidis, Radix Scutellariae and Radix isatidis could significantly inhibit the H. pylori activity with their MIC less than 7.8 mg/mL, suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H. pylori infection.

CONCLUSION:

Rhizoma Coptidis, Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H. pylori.

PMID:
21105198
PMCID:
PMC2992683
[PubMed - indexed for MEDLINE]
Free PMC Article
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