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Exp Hematol. 1978 Aug;6(7):590-4.

Mobilization of CFU-C by exercise and ACTH induced stress in man.


This study was designed to investigate physiological factors that affect blood CFU-C numbers. Exercise was found to produce a fourfold rise in blood colony forming cells, and a twofold rise in cluster forming cells accompanied by a lymphocytosis. ACTH-induced stress caused a twofold rise in blood colony and cluster forming cells accompanied by a neutrophil leucocytosis. The results suggest that blood CFU-C exchange with a large marginal pool as well as a bone marrown pool. The procedures described could be exploited in the use of leukapheresed nucleated cells as a source of stem cells for bone marrow transplantation.

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