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Lab Chip. 2011 Feb 21;11(4):723-6. doi: 10.1039/c0lc00160k. Epub 2010 Nov 22.

Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform.

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Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.


A novel active valving technique, whereby paraffin wax plugs in microchannels on a centrifugal microfluidic platform are actuated using focused infrared (IR) radiation is demonstrated in this report. Microchannels were simultaneously or sequentially opened using a stationary IR source by forming wax plugs with similar or differing melting points. The presented wax plugs offer key advantages over current active valving techniques, including a less involved fabrication procedure, a simpler actuation process, and the ability to multiplex experiment with active valves. In addition, a new technique for automated liquid reagent storage and release on the microfluidic disc platform, based on the formation and removal of a wax layer, is demonstrated. Overall, the techniques presented in this report offer novel methods for liquid handling, separation, and storage on the centrifugal microfluidic disc platform.

[Indexed for MEDLINE]

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