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Nat Rev Genet. 2011 Jan;12(1):32-42. doi: 10.1038/nrg2899. Epub 2010 Nov 23.

Synonymous but not the same: the causes and consequences of codon bias.

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1
Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, 433 South University Avenue, Philadelphia, Pennsylvania 19104, USA. jplotkin@sas.upenn.edu

Abstract

Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology. Although recent advances in sequencing and synthetic biology have helped to resolve longstanding questions about codon bias, they have also uncovered striking patterns that suggest new hypotheses about protein synthesis. Ongoing work to quantify the dynamics of initiation and elongation is as important for understanding natural synonymous variation as it is for designing transgenes in applied contexts.

PMID:
21102527
PMCID:
PMC3074964
DOI:
10.1038/nrg2899
[Indexed for MEDLINE]
Free PMC Article
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