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Nat Neurosci. 2010 Dec;13(12):1454-6. doi: 10.1038/nn.2690.

The same synaptic vesicles drive active and spontaneous release.

Author information

1
STED Microscopy Group, European Neuroscience Institute, Deutsche Forschungsgemeinschaft Center for Molecular Physiology of the Brain/Excellence Cluster 171, Göttingen, Germany.

Abstract

Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin) in neuromuscular preparations from Drosophila, frog and mouse, as well as rat cultured neurons, we found that the same vesicles participate in active and spontaneous release.

PMID:
21102450
DOI:
10.1038/nn.2690
[Indexed for MEDLINE]

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