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Nat Neurosci. 2010 Dec;13(12):1451-3. doi: 10.1038/nn.2695.

A common origin of synaptic vesicles undergoing evoked and spontaneous fusion.

Author information

1
Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

Abstract

There is a longstanding controversy on the identity of synaptic vesicles undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested that spontaneous release is driven by a resting pool of synaptic vesicles refractory to stimulation. We found that cross-depletion of spontaneously or actively recycling synaptic vesicle pools occurred on stimulation in rat hippocampal neurons and identified the recycling pool as a major source of spontaneous release.

PMID:
21102448
DOI:
10.1038/nn.2695
[Indexed for MEDLINE]

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