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J Thorac Oncol. 2010 Dec;5(12):1883-6. doi: 10.1097/JTO.0b013e3181fbc28a.

LKB1 regulated pathways in lung cancer invasion and metastasis.

Author information

1
Department of Hematology and Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA. aimarcu@emory.edu

Abstract

Metastasis is characterized by the ability of cancer cells to invade into adjacent tissue, intravasate into blood or lymphatic vessels, and extravasate into a distant tissue. Metastatic disease is primarily responsible for the low 5-year survival rate of non-small cell lung cancer (NSCLC), and therefore, an understanding of the molecular mechanisms that regulate NSCLC metastasis is clearly warranted. The serine/threonine kinase and tumor suppressor LKB1 is mutated in 30% of NSCLC tumors, and recent evidence points to a prominent role in NSCLC metastasis. This review summarizes LKB1-dependent invasion pathways where compromised LKB1 function could promote NSCLC metastasis.

PMID:
21102257
PMCID:
PMC2995373
DOI:
10.1097/JTO.0b013e3181fbc28a
[Indexed for MEDLINE]
Free PMC Article
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