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Autophagy. 2011 Feb;7(2):231-2. Epub 2011 Feb 1.

Anti-autophagic Bcl-2: Not just an innocent bystander.

Author information

1
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, USA.

Abstract

Bcl-2, originally identified as a universal inhibitor of apoptotic cell death, has since been implicated in suppressing autophagy, the cell's quality control mechanism. Our recent study demonstrates that the anti-autophagic aspect of Bcl-2 can function as a promoter of oncogenic growth, independently of its role in apoptosis signaling. It is likely that the increase in Bcl-2 often seen in breast and other cancers might render cells error-prone by blunting autophagy, while concomitantly keeping damaged cells alive. The outcome of such a 'double hit' of Bcl-2 may synergistically promote tumor growth and increase the chance of cancer development and drug resistance.

PMID:
21099349
PMCID:
PMC3679092
DOI:
10.4161/auto.7.2.14198
[Indexed for MEDLINE]
Free PMC Article

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