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Islets. 2010 Sep-Oct;2(5):323-30. Epub 2010 Sep 1.

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.

Author information

1
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK.

Abstract

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

PMID:
21099331
PMCID:
PMC3230560
DOI:
10.4161/isl.2.5.12747
[Indexed for MEDLINE]
Free PMC Article

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