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Nucleic Acids Res. 2011 Jan;39(Database issue):D724-9. doi: 10.1093/nar/gkq1200. Epub 2010 Nov 19.

DIMA 3.0: Domain Interaction Map.

Author information

1
Department of Genome Oriented Bioinformatics, Technische Universit√§t M√ľnchen, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany.

Abstract

Domain Interaction MAp (DIMA, available at http://webclu.bio.wzw.tum.de/dima) is a database of predicted and known interactions between protein domains. It integrates 5807 structurally known interactions imported from the iPfam and 3did databases and 46,900 domain interactions predicted by four computational methods: domain phylogenetic profiling, domain pair exclusion algorithm correlated mutations and domain interaction prediction in a discriminative way. Additionally predictions are filtered to exclude those domain pairs that are reported as non-interacting by the Negatome database. The DIMA Web site allows to calculate domain interaction networks either for a domain of interest or for entire organisms, and to explore them interactively using the Flash-based Cytoscape Web software.

PMID:
21097782
PMCID:
PMC3013740
DOI:
10.1093/nar/gkq1200
[Indexed for MEDLINE]
Free PMC Article

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