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J Bacteriol. 2011 Feb;193(3):778-82. doi: 10.1128/JB.00606-10. Epub 2010 Nov 19.

The peptidoglycan of Mycobacterium abscessus is predominantly cross-linked by L,D-transpeptidases.

Author information

1
LRMA, Equipe 12, Centre de Recherches des Cordeliers, 15 rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. jean-luc.mainardi@crc.jussieu.fr

Abstract

Few therapeutic alternatives remain for the treatment of infections due to multiresistant Mycobacterium abscessus. Here we show that the peptidoglycans of the "rough" and "smooth" morphotypes contain predominantly 3→3 cross-links generated by l,d-transpeptidases, indicating that these enzymes are attractive targets for the development of efficient drugs.

PMID:
21097619
PMCID:
PMC3021224
DOI:
10.1128/JB.00606-10
[Indexed for MEDLINE]
Free PMC Article

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