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Nucleic Acids Res. 2011 Mar;39(5):1647-55. doi: 10.1093/nar/gkq1045. Epub 2010 Nov 18.

RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination.

Author information

1
Terry Fox Laboratory, BC Cancer Agency, Avenue, Vancouver, BC, V5Z 1L3, Canada.

Abstract

Telomere maintenance and DNA repair are crucial processes that protect the genome against instability. RTEL1, an essential iron-sulfur cluster-containing helicase, is a dominant factor that controls telomere length in mice and is required for telomere integrity. In addition, RTEL1 promotes synthesis-dependent strand annealing to direct DNA double-strand breaks into non-crossover outcomes during mitotic repair and in meiosis. Here, we review the role of RTEL1 in telomere maintenance and homologous recombination and discuss models linking RTEL1's enzymatic activity to its function in telomere maintenance and DNA repair.

PMID:
21097466
PMCID:
PMC3061057
DOI:
10.1093/nar/gkq1045
[Indexed for MEDLINE]
Free PMC Article

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