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IEEE Trans Biomed Eng. 2012 Mar;59(3):619-26. doi: 10.1109/TBME.2010.2093897. Epub 2010 Nov 22.

Noninvasive intracranial pressure assessment based on a data-mining approach using a nonlinear mapping function.

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Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, CA 90095-7065, USA.


The current gold standard to determine intracranial pressure (ICP) involves an invasive procedure for direct access to the intracranial compartment. The risks associated with this invasive procedure include intracerebral hemorrhage, infection, and discomfort. We previously proposed an innovative data-mining framework of noninvasive ICP (NICP) assessment. The performance of the proposed framework relies on designing a good mapping function. We attempt to achieve performance gain by adopting various linear and nonlinear mapping functions. Our results demonstrate that a nonlinear mapping function based on the kernel spectral regression technique significantly improves the performance of the proposed data-mining framework for NICP assessment in comparison to other linear mapping functions.

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